Advances in Spheroids and Organoids on a Chip

G Fang, YC Chen, H Lu, D Jin - Advanced Functional Materials, 2023 - Wiley Online Library
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …

Organoids: The current status and biomedical applications

S Yang, H Hu, H Kung, R Zou, Y Dai, Y Hu… - MedComm, 2023 - Wiley Online Library
Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Engineered organoids for biomedical applications

NR de Barros, C Wang, S Maity, A Peirsman… - Advanced Drug Delivery …, 2023 - Elsevier
As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …

Probing organoid metabolism using fluorescence lifetime imaging microscopy (FLIM): The next frontier of drug discovery and disease understanding

M Barroso, MG Monaghan, R Niesner… - Advanced Drug Delivery …, 2023 - Elsevier
Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …

A controllable perfusion microfluidic chip for facilitating the development of retinal ganglion cells in human retinal organoids

J Gong, Y Gong, T Zou, Y Zeng, C Yang, L Mo, J Kang… - Lab on a Chip, 2023 - pubs.rsc.org
Retinal organoids (ROs) derived from human pluripotent stem cells (hPSCs) have become a
promising model in vitro to recapitulate human retinal development, which can be further …

Advances in microfluidic technologies in organoid research

H Liu, Z Gan, X Qin, Y Wang… - Advanced Healthcare …, 2024 - Wiley Online Library
Organoids have emerged as major technological breakthroughs and novel organ models
that have revolutionized biomedical research by recapitulating the key structural and …

Emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: Current progress and future perspectives

J Yu, Y Yin, Y Leng, J Zhang, C Wang, Y Chen… - Advanced Drug Delivery …, 2023 - Elsevier
Retinal diseases are a rising concern as major causes of blindness in an aging society;
therapeutic options are limited, and the precise pathogenesis of these diseases remains …

Advances in human organoids-on-chips in biomedical research

Y Wang, J Qin - Life Medicine, 2023 - academic.oup.com
Organoids-on-chips is opening up new frontier of research in biomedical field by combining
organoids and organs-on-chips technology. The integrative technology offers great …

Hydrophobic recovery of PDMS surfaces in contact with hydrophilic entities: relevance to biomedical devices

T Tsuzuki, K Baassiri, Z Mahmoudi, AS Perumal… - Materials, 2022 - mdpi.com
Polydimethylsiloxane (PDMS), a silicone elastomer, is increasingly being used in health and
biomedical fields due to its excellent optical and mechanical properties. Its biocompatibility …

Establishment of advanced tumor organoids with emerging innovative technologies

Y Mao, H Hu - Cancer Letters, 2024 - Elsevier
Tumor organoids have emerged as a crucial preclinical model for multiple cancer research.
Their high establishment rates, stability, and ability to replicate key biological features of …