TCR-engineered T cell therapy in solid tumors: State of the art and perspectives
E Baulu, C Gardet, N Chuvin, S Depil - Science Advances, 2023 - science.org
T cell engineering has changed the landscape of cancer immunotherapy. Chimeric antigen
receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell …
receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell …
T-cell epitope vaccine design by immunoinformatics
A Patronov, I Doytchinova - Open biology, 2013 - royalsocietypublishing.org
Vaccination is generally considered to be the most effective method of preventing infectious
diseases. All vaccinations work by presenting a foreign antigen to the immune system in …
diseases. All vaccinations work by presenting a foreign antigen to the immune system in …
[HTML][HTML] A single autoimmune T cell receptor recognizes more than a million different peptides
L Wooldridge, J Ekeruche-Makinde… - Journal of Biological …, 2012 - ASBMB
The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides
presented at the cell surface in the context of major histocompatibility complex (MHC) …
presented at the cell surface in the context of major histocompatibility complex (MHC) …
T cell antigen discovery
AV Joglekar, G Li - Nature methods, 2021 - nature.com
T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that
recognize short peptide antigens presented on major histocompatibility complex (MHC) …
recognize short peptide antigens presented on major histocompatibility complex (MHC) …
[HTML][HTML] T cell repertoire profiling and the mechanism by which HLA-B27 causes ankylosing spondylitis
J Garrido-Mesa, MA Brown - Current rheumatology reports, 2022 - Springer
Abstract Purpose of Review Ankylosing spondylitis (AS) is strongly associated with the HLA-
B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 …
B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 …
[HTML][HTML] Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries
Background It has been previously shown that combinatorial peptide libraries are a useful
tool to characterize the binding specificity of class I MHC molecules. Compared to other …
tool to characterize the binding specificity of class I MHC molecules. Compared to other …
[HTML][HTML] Peptides, antibodies, peptide antibodies and more
N Trier, P Hansen, G Houen - International journal of molecular sciences, 2019 - mdpi.com
The applications of peptides and antibodies to multiple targets have emerged as powerful
tools in research, diagnostics, vaccine development, and therapeutics. Antibodies are …
tools in research, diagnostics, vaccine development, and therapeutics. Antibodies are …
[HTML][HTML] Predicting cross-reactivity and antigen specificity of T cell receptors
Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
Polyspecificity of T cell and B cell receptor recognition
KW Wucherpfennig, PM Allen, F Celada… - Seminars in …, 2007 - Elsevier
A recent workshop discussed the recognition of multiple distinct ligands by individual T cell
and B cell receptors and the implications of this discovery for lymphocyte biology. The …
and B cell receptors and the implications of this discovery for lymphocyte biology. The …
Cross-reactivity of T cells and its role in the immune system
G Petrova, A Ferrante, J Gorski - Critical Reviews™ in …, 2012 - dl.begellhouse.com
ABSTRACT T-cell receptors recognize peptides presented by the major histocompatibility
complex (MHC) on the surface of antigen-presenting cells (APC). The ability of the T-cell …
complex (MHC) on the surface of antigen-presenting cells (APC). The ability of the T-cell …