The mycobacterial cell envelope—a moving target

CL Dulberger, EJ Rubin, CC Boutte - Nature Reviews Microbiology, 2020 - nature.com
Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …

Virulence factors of the Mycobacterium tuberculosis complex

MA Forrellad, LI Klepp, A Gioffré, J Sabio y Garcia… - Virulence, 2013 - Taylor & Francis
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity

S Fishbein, N Van Wyk, RM Warren… - Molecular …, 2015 - Wiley Online Library
The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

Latent tuberculosis infection: myths, models, and molecular mechanisms

NK Dutta, PC Karakousis - Microbiology and Molecular Biology …, 2014 - Am Soc Microbiol
The aim of this review is to present the current state of knowledge on human latent
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …

The Stress-Responsive Alternative Sigma Factor SigB of Bacillus subtilis and Its Relatives: An Old Friend With New Functions

F Rodriguez Ayala, M Bartolini, R Grau - Frontiers in Microbiology, 2020 - frontiersin.org
Alternative sigma factors have led the core RNA polymerase (RNAP) to recognize different
sets of promoters to those recognized by the housekeeping sigma A-directed RNAP. This …

The sigma factors of Mycobacterium tuberculosis: regulation of the regulators

P Sachdeva, R Misra, AK Tyagi, Y Singh - The FEBS journal, 2010 - Wiley Online Library
One of the important determinants of virulence of Mycobacterium tuberculosis is adaptation
to adverse conditions encountered in the host cells. The ability of Mycobacterium to …

Phosphate Depletion: A Novel Trigger for Mycobacterium tuberculosis Persistence

D Rifat, WR Bishai, PC Karakousis - The Journal of infectious …, 2009 - academic.oup.com
Persistent Mycobacterium tuberculosis (MTB) likely encounters a phosphate-limited
environment within macrophage phagosomes. We studied MTB growth, antibiotic …

The genetic requirements for fast and slow growth in mycobacteria

DJV Beste, M Espasa, B Bonde, AM Kierzek… - PloS one, 2009 - journals.plos.org
Mycobacterium tuberculosis infects a third of the world's population. Primary tuberculosis
involving active fast bacterial replication is often followed by asymptomatic latent …

The PE and PPE proteins of Mycobacterium tuberculosis

S Mukhopadhyay, KN Balaji - Tuberculosis, 2011 - Elsevier
India already has earned the dubious distinction of being one of the countries with the
highest incidence of tuberculosis (TB). The conventional control measures have had little …

Mycobacterium tuberculosis transcription machinery: ready to respond to host attacks

K Flentie, AL Garner, CL Stallings - Journal of bacteriology, 2016 - Am Soc Microbiol
Regulating responses to stress is critical for all bacteria, whether they are environmental,
commensal, or pathogenic species. For pathogenic bacteria, successful colonization and …