The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

At specific stages of development, nerve and muscle cells generate spontaneous electrical
activity that is required for normal maturation of intrinsic excitability and synaptic connectivity …

Pacemaker activity of automatic cardiac myocytes controls the heartbeat in everyday life.
Cardiac automaticity is under the control of several neurotransmitters and hormones and is …

Two different Ca2+ channels exist in cardiac myocytes. While the L-type Ca2+ channel is
ubiquitous and the main source of Ca2+ for excitation–contraction coupling and pacemaker …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

This new book is the only in-depth, single-author reference on heart development. Clearly
written, with lavish color illustrations, it provides a more clinical, systematic, up-to-date …

Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without
curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial …

This authoritative book gathers together a broad range of ideas and topics that define the
field. It provides clear, concise, and comprehensive coverage of all aspects of cellular …

After the first demonstration 30 years ago that Ca2+ could permeate through two different
channels, the occurrence and role of T-type Ca2+ current, ICaT have been the matter of …

Low-voltage activated, T-type calcium channels (T-channels) are expressed in many
developing tissues and may be important in regulating important cellular phenotype …