TRPC6 is a non-selective cation channel 6 times more permeable to Ca 2+ than to Na+.
Channel homotetramers heterologously expressed have a characteristic doubly rectifying …

The Apicomplexa phylum includes a large group of obligate intracellular protozoan
parasites responsible for important diseases in humans and animals. Toxoplasma gondii is …

Toxoplasma gondii establishes a lifelong chronic infection in humans and animals. Host cell
entry and egress are key steps in the lytic cycle of this obligate intracellular parasite …

The most severe form of human malaria is caused by Plasmodium falciparum. Its virulence is
closely linked to the increase in rigidity of infected erythrocytes and their adhesion to …

Intracellular pathogens mobilize host signaling pathways of their host cell to promote their
own survival. Evidence is emerging that signal transduction elements are activated in a …

Red blood cells (RBCs) are known to function as a refuge for providing food resources and
as a shelter against the host's immune system after malaria parasite (Plasmodium) infection …

All intracellular pathogens must escape (egress) from the confines of their host cell to
disseminate and proliferate. The malaria parasite only replicates in an intracellular vacuole …

An essential step in the life cycle of malaria parasites is their egress from hepatocytes, which
enables the transition from the asymptomatic liver stage to the pathogenic blood stage of …

Highlights•Egress is a fundamental event in the biology of apicomplexan parasites.•Kinases,
a methyl transferase and a putative vesicular fusion protein regulate egress.•Signal …

ABSTRACT A crucial step in the life cycle of Plasmodium parasites is the transition from the
liver stage to the blood stage. Hepatocyte-derived merozoites reach the blood vessels of the …