C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Copper is one of the most abundant and less toxic transition metals. Nature takes advantage
of the bioavailability and rich redox chemistry of Cu to carry out oxygenase and oxidase …

Transition-metal-catalyzed C–H bond functionalizations have had an enormous influence on
organic synthesis in recent times. However, the use of low-abundance 4d and 5d metals is …

Electrochemical oxidation represents an environmentally friendly solution to conventional
methods that require caustic stoichiometric chemical oxidants. However, C–H …

C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …

A Pd-catalyzed amide-directed enantioselective hydrocarbofunctionalization of unactivated
alkenes with C–H nucleophiles has been developed using a chiral monodentate oxazoline …

An operationally simple and metal-free protocol for geometrically inaccessible C5–H
halogenation of a range of 8-substituted quinoline derivatives has been established. The …

Direct amination of arene C–H bonds is an attractive disconnection to form aniline-derived
building blocks. This transformation presents significant practical challenges; classical …

A wide range of Cu (II)-catalyzed C–H activation reactions have been realized since 2006,
however, whether a C–H metalation mechanism similar to Pd (II)-catalyzed C–H activation …

Transition metal-catalysed C–H hydroxylation is one of the most notable advances in
synthetic chemistry during the past few decades and it has been widely employed in the …