Biology of Vascular Endothelial Growth Factor | Endocrine Reviews | Oxford Academic Skip to
Main Content Advertisement Oxford Academic Journals Books Search Menu Information …

Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular
endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a …

Use of long-term constitutive expression of VEGF for therapeutic angiogenesis may be
limited by the growth of abnormal blood vessels and hemangiomas. We investigated the …

Fracture of bone disrupts its circulation and leads to necrosis and hypoxia of adjacent bone.
Under normal circumstances, fractured bone undergoes the orderly regeneration of its …

Background—Therapeutic angiogenesis, a new experimental strategy for the treatment of
vascular insufficiency, uses the administration of mediators known to induce vascular …

AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that is regulated by
hypoxia and other cellular stresses that result in diminished cellular ATP levels. Here, we …

The VHL tumor suppressor gene is inactivated in patients with von Hippel-Lindau disease
and in most sporadic clear cell renal carcinomas. Although VHL protein function remains …

The multiplicity of Notch receptors raises the question of the contribution of specific isoforms
to T-cell development. Notch3 is expressed in CD4±8±thymocytes and is down-regulated …

Angiogenesis in ischemic heart disease Page 1 TS 9 1997 Nature Publishing Group http://www.nature.com/naturemedicine
RIEVIEW Angiogenesis in ischemic heart disease Inducing the formation of new blood …

Background and Purpose Vascular endothelial growth factor (VEGF) is a mitogen for
endothelial cells and also has the potential to increase vascular permeability. Therefore, it …