Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

The number of cancer cases caused by being obese is estimated to be 20% with the
increased risk of malignancies being influenced by diet, weight change, and body fat …

Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …

Prevention of cancer remains the most promising strategy for reducing both its incidence
and the mortality due to this disease. For more than four decades, findings from …

The accumulation of advanced glycation end products (AGEs) is associated with the
complications of diabetes, kidney disease, metabolic disorders and degenerative diseases …

Sedentary lifestyle and excessive energy intake are prominent contributors to obesity; a
major risk factors for the development of insulin resistance, type 2 diabetes and …

The constitutive anabolism of cancer cells not only supports proliferation but also addicts
tumor cells to a steady influx of exogenous nutrients. Limiting access to metabolic substrates …

Objective The development of breast cancer cells is linked to hypoxia. The hypoxia-induced
factor HIF-1α influences metastasis through neovascularization. Hypoxia seems to decrease …

Reactive oxygen species induce oxidative modification of critical macromolecules. Oxygen
derived free radicals may act as potential cytotoxic intermediates inducing inflammatory and …