Growth/differentiation factor-15 (GDF-15), also named macrophage inhibitory cytokine-1, is a
divergent member of the transforming growth factor β superfamily. While physiological …

BACKGROUND Growth differentiation factor 15 (GDF-15) is expressed and secreted in
response to inflammation, oxidative stress, hypoxia, telomere erosion, and oncogene …

GDF15 has recently gained scientific and translational prominence with the discovery that its
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …

In search of metabolically regulated secreted proteins, we conducted a microarray study
comparing gene expression in major metabolic tissues of fed and fasted ob/ob mice and …

Growth/differentiation factor-15 (GDF-15) is a distant member of the transforming growth
factor β (TGF-β) superfamily and is widely expressed in multiple mammalian tissues. Its …

Abstract Growth differentiation factor 15 (GDF15) is a peptide hormone, and a divergent
member of the transforming growth factor beta (TGFβ) superfamily. In normal physiology …

In thalassemia, deficient globin-chain production during erythropoiesis results in anemia,,.
Thalassemia may be further complicated by iron overload (frequently exacerbated by blood …

Using molecular, cellular, and genetic approaches, recent studies examining the role of the
bone morphogenetic protein (BMP) family of growth factors in the reproductive system have …

MEG3 is a maternally expressed imprinted gene suggested to function as a non-coding
RNA. Our previous studies suggest that MEG3 has a function of tumor suppression. The …

Abstract GDF-15 (also MIC-1, NAG-1, PLAB, PTGFB) is a member of the TGF-β superfamily,
which is widely distributed in mammalian tissues and has been shown to play multiple roles …