Cardiovascular disease (CVD) is prevalent worldwide and remains a leading cause of
death. Although substantial progress has been made in the diagnosis and treatment of CVD …

Hypertension is a frequent condition encountered during kidney disease development and a
leading cause in its progression. Hallmark factors contributing to hypertension constitute a …

Introduction Exercise training is beneficial for reducing obesity. In particular, exercise
training can lower the catecholamine concentration in circulation. Renalase, whose …

Renalase is a novel flavoprotein, highly expressed in kidney and heart, which metabolizes
catecholamines and catecholamine-like substances via a superoxide (O2–)-dependent …

Aims Renalase, an enzyme that can metabolize catecholamine, was recently reported to
attenuate the ischaemia/reperfusion (I/R)-induced cardiac injury. This work was undertaken …

Background/Aims: Renalase, a novel flavoprotein expressed in the kidney and heart,
reduces renal tubular necrosis and apoptosis, which suggests that it might protect against …

Background Repeated administration of cisplatin causes CKD. In previous studies, we
reported that the kidney-secreted survival protein renalase (RNLS) and an agonist peptide …

The cellular mechanisms and signaling network that guide the cardiac disease
pathophysiology are inextricably intertwined, which explains the current scarcity of effective …

Background Blood pressure is acutely regulated by the sympathetic nervous system through
the action of vasoactive hormones such as epinephrine, norepinephrine, and dopamine …

Elevated levels of plasma catecholamines accompany ischemic AKI, possibly contributing
the inflammatory response. Renalase, an amine oxidase secreted by the proximal tubule …