Excess dietary salt is a major cause of hypertension. Nevertheless, the specific mechanisms
by which salt increases arterial constriction and peripheral vascular resistance, and thereby …

Non-invasive ultrasonic neural modulation (UNM), a non-invasive technique with enhanced
spatial focus compared to conventional electrical neural modulation, has attracted much …

Acid-sensing ion channels are proton-activated, sodium-selective channels composed of
three subunits, and are members of the superfamily of epithelial sodium channels …

Neurons convert synaptic or sensory inputs into cellular outputs. It is not well understood
how a single neuron senses, processes multiple stimuli, and generates distinct neuronal …

A major gap in our understanding of sensation is how a single sensory neuron can
differentially respond to a multitude of different stimuli (polymodality), such as propio-or …

All animals use a sophisticated array of receptor proteins to sense their external and internal
environments. Major advances have been made in recent years in understanding the …

Gentle touch sensation in Caenorhabditis elegans is mediated by the MEC-4/MEC-10
channel complex, which is expressed exclusively in six touch receptor neurons (TRNs). The …

Visceral pain is the cardinal symptom of functional gastrointestinal (GI) disorders such as the
irritable bowel syndrome (IBS) and the leading cause of patients' visit to gastroenterologists …

The founding members of the superfamily of DEG/ENaC ion channel proteins are C. elegans
proteins that form mechanosensitive channels in touch and pain receptors. For more than a …

Mammalian neuronal DEG/ENaC channels known as ASICs (a cid‐s ensing i on c hannels)
mediate sensory perception and memory formation. ASICS are closed at rest and are gated …