The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020
Y Liu, C Liang, L Xin, X Ren, L Tian, X Ju, H Li… - European journal of …, 2020 - Elsevier
This review fully describes the coronavirus 3CL pro peptidomimetic inhibitors and
nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the …
nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the …
Isatin and its derivatives: a survey of recent syntheses, reactions, and applications
R Kakkar - MedChemComm, 2019 - pubs.rsc.org
Isatin (1H-indole-2, 3-dione) and its derivatives represent an important class of heterocyclic
compounds that can be used as precursors for drug synthesis. Since its discovery, a lot of …
compounds that can be used as precursors for drug synthesis. Since its discovery, a lot of …
Viral reverse transcriptases
L Menéndez-Arias, A Sebastián-Martín, M Álvarez - Virus research, 2017 - Elsevier
Reverse transcriptases (RTs) play a major role in the replication of Retroviridae,
Metaviridae, Pseudoviridae, Hepadnaviridae and Caulimoviridae. RTs are enzymes that are …
Metaviridae, Pseudoviridae, Hepadnaviridae and Caulimoviridae. RTs are enzymes that are …
Current medicinal chemistry strategies in the discovery of novel HIV-1 ribonuclease H inhibitors
L Zhang, F Wei, J Zhang, C Liu… - European Journal of …, 2022 - Elsevier
During HIV-1 genome replication, the viral reverse transcriptase-associated ribonuclease H
(RT-associated RNase H) activity hydrolyzes the RNA strand of RNA/DNA heteroduplex …
(RT-associated RNase H) activity hydrolyzes the RNA strand of RNA/DNA heteroduplex …
Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus
Abstract Ribonucleases H (RNases H) are endonucleolytic enzymes, evolutionarily related
to retroviral integrases, DNA transposases, resolvases and numerous nucleases. RNases H …
to retroviral integrases, DNA transposases, resolvases and numerous nucleases. RNases H …
Recent advances on dual inhibitors targeting HIV reverse transcriptase associated polymerase and ribonuclease H
JX Kang, GK Zhao, XM Yang, MX Huang… - European Journal of …, 2023 - Elsevier
Reverse transcriptase (RT) plays an indispensable role in the replication of human
immunodeficiency virus (HIV) through its associated polymerase and ribonuclease H …
immunodeficiency virus (HIV) through its associated polymerase and ribonuclease H …
Sampling of protein conformational space using hybrid simulations: A critical assessment of recent methods
Recent years have seen several hybrid simulation methods for exploring the conformational
space of proteins and their complexes or assemblies. These methods often combine fast …
space of proteins and their complexes or assemblies. These methods often combine fast …
In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds
In a search for natural compounds with anti-HIV-1 activity, we studied the effect of the
ethanolic extract obtained from leaves, bark, and peels of Punica granatum L. for the …
ethanolic extract obtained from leaves, bark, and peels of Punica granatum L. for the …
Analogs of the catechol derivative dynasore inhibit HIV-1 ribonuclease H, SARS-CoV-2 nsp14 exoribonuclease, and virus replication
Viral replication often depends on RNA maturation and degradation processes catalyzed by
viral ribonucleases, which are therefore candidate targets for antiviral drugs. Here, we …
viral ribonucleases, which are therefore candidate targets for antiviral drugs. Here, we …
Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase
R Meleddu, S Distinto, A Corona… - Journal of enzyme …, 2017 - Taylor & Francis
Abstract A series of 3-3-{2-[2-3-methyl-4-phenyl-2, 3-dihydro-1, 3-thiazol-2-ylidene] hydrazin-
1-ylidene-2, 3-dihydro-1H-indol-2-one derivatives has been designed and synthesized to …
1-ylidene-2, 3-dihydro-1H-indol-2-one derivatives has been designed and synthesized to …