Harnessing Artificial Intelligence in Multimodal Omics Data Integration: Paving the Path for the Next Frontier in Precision Medicine
The integration of multiomics data with detailed phenotypic insights from electronic health
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …
Employing Informatics Strategies in Alzheimer's Disease Research: A Review from Genetics, Multiomics, and Biomarkers to Clinical Outcomes
Alzheimer's disease (AD) is a critical national concern, affecting 5.8 million people and
costing more than 250 billion annually. However, there is no available cure. Thus, effective …
costing more than 250 billion annually. However, there is no available cure. Thus, effective …
Alzheimer's disease diagnosis from multi-modal data via feature inductive learning and dual multilevel graph neural network
Multi-modal data can provide complementary information of Alzheimer's disease (AD) and
its development from different perspectives. Such information is closely related to the …
its development from different perspectives. Such information is closely related to the …
A comparative meta-analysis of structural magnetic resonance imaging studies and gene expression profiles revealing the similarities and differences between late …
L Zhao, L Niu, H Dai, TMC Lee, R Huang… - Psychological …, 2024 - cambridge.org
BackgroundLate-life depression (LLD) predisposes individuals to cognitive decline, often
leading to misdiagnoses as mild cognitive impairment (MCI). Voxel-based morphometry …
leading to misdiagnoses as mild cognitive impairment (MCI). Voxel-based morphometry …
[HTML][HTML] Multivariate mediation analysis with voxel-based morphometry revealed the neurodegeneration pathways from genetic variants to Alzheimer's Disease
Neurodegenerative processes are increasingly recognized as potential causative factors in
Alzheimer's disease (AD) pathogenesis. While many studies have leveraged mediation …
Alzheimer's disease (AD) pathogenesis. While many studies have leveraged mediation …
Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
G Deiana, J He, B Cabrera-Mendoza, R Ciccocioppo… - medRxiv, 2024 - medrxiv.org
To investigate the pleiotropic mechanisms linking brain structure and function to alcohol
drinking and tobacco smoking, we integrated genome-wide data generated by the GWAS …
drinking and tobacco smoking, we integrated genome-wide data generated by the GWAS …
Multiscale Estimation of Morphometricity for Revealing Neuroanatomical Basis of Cognitive Traits
Morphometricity examines the global statistical association between brain morphology and
an observable trait, and is defined as the proportion of the trait variation attributable to brain …
an observable trait, and is defined as the proportion of the trait variation attributable to brain …