[HTML][HTML] The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
SJ Vervoort, SA Welsh, JR Devlin, E Barbieri… - Cell, 2021 - cell.com
Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing …
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing …
Histone variants shape chromatin states in Arabidopsis
B Jamge, ZJ Lorković, E Axelsson, A Osakabe… - Elife, 2023 - elifesciences.org
How different intrinsic sequence variations and regulatory modifications of histones combine
in nucleosomes remain unclear. To test the importance of histone variants in the …
in nucleosomes remain unclear. To test the importance of histone variants in the …
Structural variation of the coding and non-coding human pharmacogenome
Genetic variants in drug targets and genes encoding factors involved in drug absorption,
distribution, metabolism and excretion (ADME) can have pronounced impacts on drug …
distribution, metabolism and excretion (ADME) can have pronounced impacts on drug …
[HTML][HTML] A concise guide to essential R packages for analyses of DNA, RNA, and proteins
R is widely regarded as unrivalled by other high-level programming languages for its
statistical functions. The popularity of R as a statistical language has led many to overlook its …
statistical functions. The popularity of R as a statistical language has led many to overlook its …
Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice
T Venit, O Sapkota, WS Abdrabou… - Nature …, 2023 - nature.com
Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that
nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly …
nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly …
Relocalizing transcriptional kinases to activate apoptosis
Kinases are critical regulators of cellular function that are commonly implicated in the
mechanisms underlying disease. Most drugs that target kinases are molecules that inhibit …
mechanisms underlying disease. Most drugs that target kinases are molecules that inhibit …
SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma
CJ Hughes, KM Fields, EP Danis, JY Hsu… - Nature …, 2023 - nature.com
Ewing sarcoma (ES), which is characterized by the presence of oncogenic fusion proteins
such as EWS/FLI1, is an aggressive pediatric malignancy with a high rate of early …
such as EWS/FLI1, is an aggressive pediatric malignancy with a high rate of early …
[HTML][HTML] Redistribution of the chromatin remodeler Brg1 directs smooth muscle–derived adventitial progenitor–to–myofibroblast differentiation and vascular fibrosis
AJ Jolly, S Lu, AM Dubner, KA Strand, MF Mutryn… - JCI insight, 2023 - ncbi.nlm.nih.gov
Vascular smooth muscle–derived Sca1+ adventitial progenitor (AdvSca1-SM) cells are
tissue-resident, multipotent stem cells that contribute to progression of vascular remodeling …
tissue-resident, multipotent stem cells that contribute to progression of vascular remodeling …
Plyranges: a grammar of genomic data transformation
Bioconductor is a widely used R-based platform for genomics, but its host of complex
genomic data structures places a cognitive burden on the user. For most tasks, the GRanges …
genomic data structures places a cognitive burden on the user. For most tasks, the GRanges …
Genomic vulnerability of a freshwater salmonid under climate change
Understanding the adaptive potential of populations and species is pivotal for minimizing the
loss of biodiversity in this era of rapid climate change. Adaptive potential has been estimated …
loss of biodiversity in this era of rapid climate change. Adaptive potential has been estimated …