Rheumatoid arthritis (RA) is a systemic, autoimmune disease characterized by joint
involvement, with progressive cartilage and bone destruction. Genetic and environmental …

The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Vaccination is a groundbreaking approach in preventing and controlling infectious diseases.
However, the effectiveness of vaccines can be greatly enhanced by the inclusion of …

Inflammasomes are protein complexes formed upon encounter of microbial or damage-
associated stimuli. The main output of inflammasome assembly is activation of caspase-1, a …

It is recognized that a chronic low-grade inflammation and an activation of the immune
system are involved in the pathogenesis of obesity-related insulin resistance and type 2 …

NOD-like receptor protein 3 (NLRP3), an important intracellular pattern recognition receptor,
is a component of the NLRP3 inflammasome along with apoptosis-associated speck-like …

Macrophages undergo profound metabolic reprogramming upon sensing infectious and
sterile stimuli. This metabolic shift supports and regulates essential innate immune functions …

Inflammation with macrophage infiltration is a key feature of atherosclerosis. Although the
mechanisms had been unclear, emerging evidence unveiled that NLRP3 inflammasomes …

Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to
Western diet. Three major food classes that promote acne are: 1) hyperglycemic …