Neural circuit function can be drastically affected by variations in the number of cells that are
produced during development or by a reduction in adult cell number owing to disease. For …

During central nervous system (CNS) development, neural progenitor cells (NPCs) generate
neurons and glia in two different ways. In direct neurogenesis, daughter cells differentiate …

Summary EGFR-RAS-ERK signaling promotes growth and proliferation in many cell types,
and genetic hyperactivation of RAS-ERK signaling drives many cancers. Yet, despite …

Ferroptosis, as a new type of cell death caused by lipid peroxidation, has attracted much
attention since it was first identified in 2012. A lot of progress has been made in unraveling …

In Drosophila, neural stem cells or neuroblasts (NBs) acquire different identities according to
their site of origin in the embryonic neuroectoderm. Their identity determines the number of …

A brain consists of numerous distinct neurons arising from a limited number of progenitors,
called neuroblasts in Drosophila. Each neuroblast produces a specific neuronal lineage. To …

How the developmental potential of differentiating stem cell progeny becomes rapidly and
stably restricted following asymmetric stem cell division is unclear. In the fly larval brain …

In order to boost the number and diversity of neurons generated from neural stem cells,
intermediate neural progenitors (INPs) need to maintain their homeostasis by avoiding both …

Intermediate neural progenitors (INPs) need to avoid both dedifferentiation and
differentiation during neurogenesis, but the underlying mechanisms are not well understood …

Stem cells that indirectly generate differentiated cells through intermediate progenitors
drives vertebrate brain evolution. Due to a lack of lineage information, how stem cell …