Advances in methods and concepts provide new insight into antibiotic fluxes across the bacterial membrane

J Vergalli, M Réfrégiers, P Ruggerone… - Communications …, 2024 - nature.com
The sophisticated envelope of Gram-negative bacteria modulates the uptake of small
molecules in a side-chain-sensitive manner. Despite intensive theoretical and experimental …

A Comprehensive Review of Antimicrobial Agents Against Clinically Important Bacterial Pathogens: Prospects for Phytochemicals

S Ghosh, S Basu, A Anbarasu… - Phytotherapy …, 2025 - Wiley Online Library
Antimicrobial resistance (AMR) hinders the effective treatment of a range of bacterial
infections, posing a serious threat to public health globally, as it challenges the currently …

Single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenic Staphylococcus aureus communities

J Hira, B Singh, T Halder, A Mahmutovic… - Communications …, 2024 - nature.com
Isogenic bacterial cell populations are phenotypically heterogenous and may include
subpopulations of antibiotic tolerant or heteroresistant cells. The reversibility of these …

Synthesis and preclinical evaluation of novel 18F-vancomycin-based tracers for the detection of bacterial infections using positron emission tomography

GB Spoelstra, SN Blok, L Reali Nazario… - European Journal of …, 2024 - Springer
Introduction Bacterial infections are a major problem in medicine, and the rapid and
accurate detection of such infections is essential for optimal patient outcome. Bacterial …

Antibacterial Activity of Amphiphilic Janus Nanoparticles Enhanced by Polycationic Ligands

JT Wiemann, D Nguyen, S Bhattacharyya… - ACS Applied Nano …, 2023 - ACS Publications
The rapid rise of antibiotic resistance has become a critical global health concern,
necessitating the development of alternative treatments, such as antibacterial nanoparticles …

A Far-Red Fluorescent Probe to Visualize Gram-Positive Bacteria in Patient Samples

K Jantarug, V Tripathi, B Morin, A Iizuka… - ACS Infectious …, 2024 - ACS Publications
Gram-positive bacteria, in particular Staphylococcus aureus (S. aureus), are the leading
bacterial cause of death in high-income countries and can cause invasive infections at …

Bacteria-targeted imaging using vancomycin-based positron emission tomography tracers can distinguish infection from sterile inflammation

GB Spoelstra, LM Braams, FFA IJpma… - European Journal of …, 2024 - Springer
Introduction Bacterial infections pose major challenges in medicine. To guide effective
infection treatment, faster and more accurate diagnostic modalities are needed. Bacteria …

Investigating the effect of fusion partners on the enzymatic activity and thermodynamic stability of poly (ethylene terephthalate) degrading enzymes

L Oliveira, A Cahill, L Wuscher, KR Green… - Faraday …, 2024 - pubs.rsc.org
Plastics are a cornerstone of the modern world, yet the durable material properties that we
have come to depend upon have made them recalcitrant environmental pollutants …

Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

KK Lee, U Łapińska, G Tolle, W Phetsang… - bioRxiv, 2024 - biorxiv.org
Antimicrobial resistance threatens the viability of modern medical interventions. There is a
dire need of developing novel approaches to counter resistance mechanisms employed by …

High-throughput single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenic Staphylococcus aureus …

J Hira, B Singh, T Halder, A Mahmutovic, C Ajayi… - bioRxiv, 2023 - biorxiv.org
Isogenic bacterial cell populations are phenotypically heterogenous and may include
subpopulations of antibiotic tolerant or heteroresistant cells. The reversible nature of these …