Background Vitamin B12 is an essential micronutrient in humans needed for health
maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and …

Long QT syndrome (LQTS) is a complex disorder of cardiac electrophysiology. It is
characterized by delayed myocardial polarization leading to QT prolongation and alterations …

Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading
cause of disability worldwide. Despite twin studies indicating its modest heritability (~ 30 …

Background Racial differences in electrocardiographic (ECG) characteristics and prognostic
significance among Whites and Asians are not well described. Methods and Results We …

Background Indigenous women have higher rates of chronic disease than Indigenous men
and non-Indigenous women. Long QT syndrome (LQTS) can be inherited or acquired; the …

QT interval length is an important risk factor for adverse cardiovascular outcomes; however,
the genetic architecture of QT interval remains incompletely understood. We conducted a …

The phase III MAX clinical trial randomised patients with metastatic colorectal cancer
(mCRC) to receive first-line capecitabine chemotherapy alone or in combination with the anti …

Background Some cancer patients derive limited benefit from anti-angiogenic therapy or
discontinuation due to adverse reactions. Vascular endothelial growth factor receptor 2 …

Haplotyping or determination of genetic phase has always played a pivotal role in MHC
(HLA studies) both in helping to understand inheritance patterns in diseases such as type 1 …

Despite the recent explosion of machine learning applied to medical data, very few studies
have examined algorithmic bias in any meaningful manner, comparing across algorithms …