The p53 tumour suppressor is modified through mutation or changes in expression in most
cancers, leading to the altered regulation of hundreds of genes that are directly influenced …

In the years that have passed since the publication of Wolfram Saenger's classic book on
nucleic acid structure (Saenger, 1984), a considerable amount of new data has been …

Telomeric DNA of a variety of vertebrates including humans contains the tandem repeat d
(TTAGGG) n. We have investigated the structural properties of the human telomeric repeat …

Tumor suppressor p53 is a transcription factor that transactivates a wide range of genes,
including those in DNA repair, cell cycle arrest, apoptosis and its own degradation. To …

Little is known about the mechanisms that regulate differential transactivation by p53. We
developed a system in the yeast Saccharomyces cerevisiae that addresses p53 …

Software packages NUFARM and NUCGEN, are described, which can be used to
understand sequence directed structural variations in nucleic acids, by analysis and …

DNA binding activity of p53 is crucial for its tumor suppressor function. Our recent studies
have shown that four molecules of the DNA binding domain of human p53 (p53DBD) bind …

The tumor suppressor p53 regulates downstream genes in response to many cellular
stresses and is frequently mutated in human cancers. Here, we report the use of a …

Abstract Grainyhead (Grh)/CP2 transcription factors are highly conserved in multicellular
organisms as key regulators of epithelial differentiation, organ development and skin barrier …

The structure and biological function of the DNA double helix are based on interactions
recognizing sequence complementarity between two single strands of DNA. A single DNA …