The erector spinae plane (ESP) block is an emerging regional anesthetic technique with
significant potential for clinical benefit. Nevertheless, its exact mechanism (s) of action has …

Background Fascial plane blocks (FPBs) target the space between two fasciae, rather than
discrete peripheral nerves. Despite their popularity, their mechanisms of action remain …

A potential treatment for paralysis resulting from spinal cord injury is to route control signals
from the brain around the injury by artificial connections. Such signals could then control …

Results: Numbers of peripheral lymphocytes and those of T4 lymphocytes were increased in
the groups given cimetidine or ranitidine; however, no fixed result was obtained in the …

KCNQ (KV7) potassium channels underlie subthreshold M-currents that stabilize the
neuronal resting potential and prevent repetitive firing of action potentials. Here, antibodies …

Local anesthetics have been used clinically for more than a century, but new insights into
their mechanisms of action and their interaction with biological systems continue to surprise …

Mutations that reduce the function of KCNQ2 channels cause neuronal hyperexcitability,
manifested as epileptic seizures and myokymia. These channels are present in nodes of …

Prasanna N, Subbarao CV, Gutmann JL. The efficacy of preoperative oral medication of
lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in …

Axonal conduction velocity varies according to the level of preceding impulse activity. In
unmyelinated axons this typically results in a slowing of conduction velocity and a parallel …

Background Nociceptive-selective local anesthesia is produced by entry of the permanently
charged lidocaine-derivative QX-314 into nociceptors when coadministered with capsaicin …