The assembly of a new growth cone is a prerequisite for axon regeneration after injury.
Creation of a new growth cone involves multiple processes, including calcium signalling …

Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because
these act in parallel, no single intervention has been sufficient to enable full regeneration of …

mRNAs are transported, localized, and translated in axons of sensory neurons. However,
little is known about the full repertoire of transcripts present in embryonic and adult sensory …

Cue-directed axon guidance depends partly on local translation in growth cones. Many
mRNA transcripts are known to reside in developing axons, yet little is known about their …

Efficient neuronal function depends on the continued modulation of the local neuronal
proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at …

Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral
neurons. The involvement of importins in retrograde transport suggests that transcription …

Unlike neurons in the central nervous system (CNS), injured neurons in the peripheral
nervous system (PNS) can regenerate their axons and reinnervate their targets. However …

microRNAs (miRNAs) constitute a novel class of small, noncoding RNAs that act as negative
post-transcriptional regulators of gene expression. Although the nervous system is a …

Although neurons execute a cell intrinsic program of axonal growth during development,
following the establishment of connections, the developmental growth capacity declines …

Exosomes, nano‐sized extracellular vesicles, are produced via the endosomal pathway and
released in the extracellular space upon fusion of multivesicular bodies with the plasma …