Biopolymers are a leading class of functional material suitable for high-value applications
and are of great interest to researchers and professionals across various disciplines …

Fluorescence microscopy is an invaluable tool in the biosciences, a genuine workhorse
technique offering exceptional contrast in conjunction with high specificity of labelling with …

Stochastic thermodynamics as reviewed here systematically provides a framework for
extending the notions of classical thermodynamics such as work, heat and entropy …

Since their invention in 1986 by Arthur Ashkin and colleagues, optical tweezers have
become an essential tool in several fields of physics, spectroscopy, biology …

Comparative genome analyses reveal that organismal complexity scales not with gene
number but with gene regulation. Recent efforts indicate that the human genome likely …

Because proteins are central to cellular function, researchers have sought to uncover the
secrets of how these complex macromolecules execute such a fascinating variety of …

It has become customary to conceptualize the living cell as an intricate piece of machinery,
different to a man-made machine only in terms of its superior complexity. This familiar …

Single-molecule measurements of biomolecules can provide information about the
molecular interactions and kinetics that are hidden in ensemble measurements. However …

Allostery is an intrinsic property of many globular proteins and enzymes that is
indispensable for cellular regulatory and feedback mechanisms. Recent theoretical and …

We studied the coupled binding and folding of α-synuclein, an intrinsically disordered
protein linked with Parkinson's disease. Using single-molecule fluorescence resonance …