The pathoetiology and pathophysiology of motor neuron loss in amyotrophic lateral sclerosis
(ALS) are still to be determined, with only a small percentage of ALS patients having a …

Amyotrophic lateral sclerosis (ALS) is described as a fatal and rapidly progressive
neurodegenerative disorder caused by the degeneration of upper motor neurons in the …

Aging is characterized by the accumulation of proteins that display amyloid-like behavior.
However, the molecular mechanisms by which these proteins arise remain unclear. Here …

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurological disease affecting
both upper and lower motor neurons. In the United States alone, there are 16,000–20,000 …

Abstract Phosphodiesterase 7 (PDE7) specifically hydrolyzes cyclic adenosine
monophosphate (cAMP), a second messenger that plays essential roles in cell signaling …

Background Amyotrophic lateral sclerosis (ALS) is a progressively fatal, neurodegenerative
disease associated with both motor and non-motor symptoms, including frontotemporal …

Amyotrophic Lateral Sclerosis (ALS) is a rare neurogenerative disorder whose median
survival ranges from 2 to 4 years after symptomatic onset. Therefore, the global Quality of …

Objective: To understand current genetic testing practices at Canadian ALS clinics. Methods:
An online survey and phone interviews, with clinicians practicing in 27 ALS clinics in …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the first
and second motoneurons (MNs), associated with muscle weakness, paralysis and finally …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to death
by progressive paralysis and respiratory failure within 2-4 years of onset. About 90-95% of …