Bone matrix non-collagenous proteins in tissue engineering: Creating new bone by mimicking the extracellular matrix

MS Carvalho, JMS Cabral, CL da Silva, D Vashishth - Polymers, 2021 - mdpi.com
Engineering biomaterials that mimic the extracellular matrix (ECM) of bone is of significant
importance since most of the outstanding properties of the bone are due to matrix …

Biomineralization‐inspired material design for bone regeneration

D de Melo Pereira, P Habibovic - Advanced healthcare …, 2018 - Wiley Online Library
Synthetic substitutes of bone grafts, such as calcium phosphate–based ceramics, have
shown some good clinical successes in the regeneration of large bone defects and are …

Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals

W Dai, Y Wang, T Yang, J Wang, W Wu… - Cell communication and …, 2019 - Springer
Abstract Background C-Type Lectin Domain Family 3 Member B (CLEC3B), is down-
regulated in serum and tumor tissues in different cancers including hepatocellular …

Identification of tetranectin-targeting monoclonal antibodies to treat potentially lethal sepsis

W Chen, X Qiang, Y Wang, S Zhu, J Li… - Science translational …, 2020 - science.org
For the clinical management of sepsis, antibody-based strategies have only been attempted
to antagonize proinflammatory cytokines but not yet been tried to target harmless proteins …

CLEC3B as a potential prognostic biomarker in hepatocellular carcinoma

XW Xie, SS Jiang, X Li - Frontiers in molecular biosciences, 2021 - frontiersin.org
C-Type Lectin Domain Family 3 Member B (CLEC3B) encodes proteins associated with
tumor invasion and metastasis. However, the interrelation between CLEC3B gene …

[HTML][HTML] Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy

CD Collier, BS Hausman, SH Zulqadar, ES Din… - Bone reports, 2020 - Elsevier
Purpose The classic fracture model, described by Bonnarens and Einhorn in 1984, enlists a
blunt guillotine to generate a closed fracture in a pre-stabilized rodent femur. However, in …

Tetranectin, a potential novel diagnostic biomarker of heart failure, is expressed within the myocardium and associates with cardiac fibrosis

K McDonald, N Glezeva, P Collier, J O'Reilly… - Scientific Reports, 2020 - nature.com
Heart failure (HF) screening strategies require biomarkers to predict disease manifestation
to aid HF surveillance and management programmes. The aim of this study was to validate a …

Tetranectin as a potential biomarker for stable coronary artery disease

Y Chen, H Han, X Yan, F Ding, X Su, H Wang… - Scientific reports, 2015 - nature.com
This cross-sectional study tested the hypothesis that decreased serum levels of tetranectin
(TN), a regulator of the fibrinolysis and proteolytic system, is associated with the presence …

Insight into the function of tetranectin in human diseases: A review and prospects for tetranectin-targeted disease treatment

S Iram, S Rahman, I Choi, J Kim - Heliyon, 2024 - cell.com
Tetranectin (TN), a serum protein, is closely associated with different types of cancers. TN
binds plasminogen and promotes the proteolytic activation of plasminogen into plasmin …

Gingival exudatome dynamics implicate inhibition of the alternative complement pathway in the protective action of the C3 inhibitor Cp40 in nonhuman primate …

N Bostanci, K Bao, X Li, T Maekawa… - Journal of proteome …, 2018 - ACS Publications
Periodontitis is a prevalent chronic inflammatory disease associated with dysbiosis.
Although complement inhibition has been successfully used to treat periodontitis in animal …