Resistance to EGFR inhibitors (EGFRi) presents a major obstacle in treating non-small cell
lung cancer (NSCLC). One of the most exciting new ways to find potential resistance …

CRISPR screens have empowered the high-throughput dissection of gene functions;
however, more explicit genetic elements, such as codons of amino acids, require thorough …

Heterotrimeric G proteins can be regulated by posttranslational modifications, including
ubiquitylation. KCTD5, a pentameric substrate receptor protein consisting of an N-terminal …

Lysosomes are central organelles for cellular degradation and energy metabolism.
Neuronal ceroid lipofuscinoses (NCLs) are a group of the most common neurodegenerative …

Despite immune checkpoint inhibitors (ICIs) have shown the greatest success in melanoma
treatment, only a subset of melanoma patients responds well to ICIs. Thus, identifying …

Colorectal cancer (CRC) is the second leading cause of cancer mortality worldwide.
However, the molecular mechanisms underlying CRC progression remain to be further …

Introduction KCTD15 encodes an oligomeric BTB domain protein reported to inhibit neural
crest formation through repression of Wnt/beta-catenin signalling, as well as transactivation …

Abstract The Sonic Hedgehog (Hh) signal transduction pathway plays a critical role in many
developmental processes and, when deregulated, may contribute to several cancers …

One of the most striking features of KCTD proteins is their involvement in apparently
unrelated yet fundamental physio-pathological processes. Unfortunately, comprehensive …

Epigenetic modifications could drive some of the molecular events implicated in
proliferation, drug resistance and metastasis of pancreatic ductal adenocarcinoma (PDAC) …