Background: Inflammatory bowel disease (IBD), once considered to be a Western disease,
is increasingly being reported from India and other Asian countries. The present review …

TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of
proteins. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals …

There is rising incidence and prevalence of inflammatory bowel disease (IBD) in India
topping the Southeast Asian (SEA) countries. The common genes implicated in disease …

TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are
members of the TNF and TNFR superfamilies, respectively, with recognised roles in …

Many variants associated with complex traits are in noncoding regions and contribute to
phenotypes by disrupting regulatory sequences. To characterize these variants, we …

Tumor necrosis factor (TNF)-like cytokine 1A (TL1A) is a member of the TNF superfamily of
proteins (TNFSF15), which signals through association with death domain receptor 3 (DR3) …

Inflammatory bowel disease (IBD) in recent times is causing a significant healthcare burden
as both ulcerative colitis and Crohn's disease (CD) require lifelong therapy and constant …

Purpose Previous studies revealed an association of tumor necrosis factor super family-15
(TNFSF15) gene polymorphisms with several autoimmune diseases, but their roles in the …

Background Interleukin (IL)-17-producing γδT (γδT17) cells mediate inflammatory responses
in barrier tissues. Dysregulated γδT17 cell activation can lead to the overproduction of IL-17 …

Purpose: T cells play an important role in the pathogenesis of uveitis. Recent studies have
indicated that the TNFSF15 gene that encodes the TL1A protein can regulate the …