Bilirubin is widely known as an end product of heme metabolism. Very high levels of serum
bilirubin lead to its accumulation in the brain, causing kernicterus. 1, 2 Almost all newborns …

Background: Lipid oxidation and formation of oxygen radicals are important elements of
arterial plaque formation and atherosclerosis, and are involved in the pathophysiology of …

A polymorphism in the promoter of the UDP-glucuronosyltransferase 1 (UGT1A1) gene has
been shown to cause Gilbert syndrome, a benign form of unconjugated bilirubinemia …

Heme oxygenase (HO) catalyzes the conversion of heme to carbon monoxide, iron, and
biliverdin, which is immediately reduced to bilirubin (BR). Two HO active isozymes exist …

Bilirubin is the end product of heme catabolism formed during a process that involves
oxidation-reduction reactions and conserves iron body stores. Unconjugated …

The heme oxygenase (HO) and nitric oxide (NO) synthase (NOS) systems display notable
similarities as well as differences. HO and NOS are both oxidative enzymes using NADPH …

Abstract von Willebrand Factor (vWF) was found to mediate platelet influx during the early
phase of liver regeneration in mice. Furthermore, increased vWF‐antigen (vWF‐Ag) levels …

Bilirubin, the principal bile pigment, is the end product of heme catabolism. For many years,
bilirubin was thought to have no physiological function other than that of a waste product of …

The survival signal elicited by the phosphatidylinositol 3-kinase (PI3K)/Akt1 pathway has
been correlated with inactivation of pro-apoptotic proteins and attenuation of the general …

As aspects of basic science come to play an increasingly prominent role in clinical medicine,
heme oxygenase-1 is one of several molecules emerging as a central player in diseases of …