Extracellular matrix is rich in biomolecules including structural proteins,
glycosaminoglycans, and small molecules that are important for the maintenance and repair …

Abstract Development of cardiac fibrosis and arrhythmias is controlled by the activity of and
communication between cardiomyocytes and fibroblasts in the heart. Myocyte-fibroblast …

Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great
potential for myocardial regeneration and in vitro tissue modeling. However, its applications …

Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm
diseases. The most advanced technologies use flexible integrated electronics; however, the …

Electrically active constructs can have a beneficial effect on electroresponsive tissues, such
as the brain, heart, and nervous system. Conducting polymers (CPs) are being considered …

The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

Heterocellular electrotonic coupling between cardiac myocytes and non-excitable
connective tissue cells has been a long-established and well-researched fact in vitro …

Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside
the body. The in vivo environment, particularly constant electromechanical stimulation, is …

In vitro models incorporating the complexity and function of adult human tissues are highly
desired for translational research. Whilst vital slices of human myocardium approach these …

Translation of novel therapies from bench to bedside is hampered by profound disparities
between animal and human genetics and physiology. The ability to test for efficacy and …