Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for
Pathogenesis* | Endocrine Reviews | Oxford Academic Skip to Main Content Advertisement …

Background and Methods Mutations in the estrogen-receptor gene have been thought to be
lethal. A 28-year-old man whose estrogen resistance was caused by a disruptive mutation in …

Elwood Jensen and Jack Gorski had spent 10 yr providing experimental evidence to support
the concept of an intracellular “receptor” protein for steroid hormones. Their combined work …

Estradiol production is most commonly thought of as an endocrine product of the ovary;
however, there are many tissues that have the capacity to synthesize estrogens from …

Estrogens influence the differentiation and maintenance of reproductive tissues and affect
lipid metabolism and bone remodeling. Two estrogen receptors (ERs) have been identified …

Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …

Somatic growth and maturation are influenced by a number of factors that act independently
or in concert to modify an individual's genetic potential. The secular trend in height and …

Premature ovarian insufficiency (POI) is one form of female infertility, defined by loss of
ovarian activity before the age of 40 and characterized by amenorrhea (primary or …

▪ Abstract There is growing awareness that androgens and estrogens have general
metabolic roles that are not directly involved in reproductive processes. These include …