Cellular homeostasis and adaptation to various environmental conditions are importantly
regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling …

Autophagy refers to a ubiquitous set of catabolic pathways required to achieve proper
cellular homeostasis. Aberrant autophagy has been implicated in a multitude of diseases …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Autophagy sustains cellular homeostasis and metabolism in numerous diseases. By
regulating cancer metabolism, both tumor and microenvironmental autophagy promote …

Although molecular targeted therapies have recently displayed therapeutic effects in acute
myeloid leukemia (AML), limited response and acquired resistance remain common …

The incidence and mortality of cancer are increasing, making it a leading cause of death
worldwide. Conventional treatments such as surgery, radiotherapy, and chemotherapy face …

Despite advances in diagnostic tools and therapeutic options, treatment resistance remains
a challenge for many cancer patients. Recent studies have found evidence that autophagy …

Lysosomes, membrane-bound organelles, play important roles in cellular processes
including endocytosis, phagocytosis, and autophagy. Lysosomes maintain cellular …

Acute myeloid leukemias (AML) are a group of aggressive hematologic malignancies
resulting from acquired genetic mutations in hematopoietic stem cells that affect patients of …

Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in 25% of
acute myeloid leukemia (AML) patients, drive leukemia progression and confer a poor …