Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective

J Zhang, PX Ma - Advanced drug delivery reviews, 2013 - Elsevier
The excellent biocompatibility and unique inclusion capability as well as powerful
functionalization capacity of cyclodextrins and their derivatives make them especially …

Cyclodextrin-based polymeric materials: synthesis, properties, and pharmaceutical/biomedical applications

F Van De Manakker, T Vermonden… - …, 2009 - ACS Publications
This review describes the synthesis, properties, and, in particular, biomedical and
pharmaceutical applications of an upcoming class of polymeric networks and assemblies …

Macrocyclic amphiphiles

K Jie, Y Zhou, Y Yao, F Huang - Chemical Society Reviews, 2015 - pubs.rsc.org
In this critical review, we summarize recent results in the investigation of macrocyclic
amphiphiles, amphiphiles based on macrocyclic frameworks. These interesting molecules …

Self-assembly of cyclodextrins and their complexes in aqueous solutions

A Ryzhakov, T Do Thi, J Stappaerts, L Bertoletti… - Journal of …, 2016 - Elsevier
Cyclodextrins (CDs) are enabling pharmaceutical excipients that can be found in numerous
pharmaceutical products worldwide. Because of their favorable toxicologic profiles, CDs are …

Cyclodextrin-based aggregates and characterization by microscopy

Y He, P Fu, X Shen, H Gao - Micron, 2008 - Elsevier
Cyclodextrin-based aggregates have been widely investigated with microscopies such as
STM, AFM, SEM, TEM, and fluorescent microscopy to obtain the direct morphology and …

Pharmaceutical applications of cyclodextrins and their derivatives

P Dhiman, M Bhatia - Journal of Inclusion Phenomena and Macrocyclic …, 2020 - Springer
Cyclodextrins (CDs) are abundantly explored in the field of medicines for the design of
various types of drug delivery systems. They are cyclic oligosaccharides carrying α (1, 4) …

Cyclodextrin bilayer vesicles

BJ Ravoo, R Darcy - Angewandte Chemie, 2000 - Wiley Online Library
Ausschließlich aus nichtionischen Cyclodextrin-Amphiphilen bestehen die schematisch
dargestellten Doppelschichtvesikel in Wasser. Die amphiphilen Komponenten wurden …

Bilayer vesicles of amphiphilic cyclodextrins: host membranes that recognize guest molecules

P Falvey, CW Lim, R Darcy… - … –a European journal, 2005 - Wiley Online Library
A family of amphiphilic cyclodextrins (6, 7) has been prepared through 6‐S‐alkylation (alkyl=
n‐dodecyl and n‐hexadecyl) of the primary side and 2‐O‐PEGylation of the secondary side …

Emergence of surfactant-free micelles from ternary solutions

S Schoettl, J Marcus, O Diat, D Touraud, W Kunz… - Chemical …, 2014 - pubs.rsc.org
Curious effects ranging from enzyme activity to anomalies in evaporation rates that have
been known for over fifty years suggest the existence and thermodynamic stability of …