Botulinum neurotoxins: biology, pharmacology, and toxicology

M Pirazzini, O Rossetto, R Eleopra… - Pharmacological …, 2017 - ASPET
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …

Pathogenicity and virulence of Clostridium botulinum

AM Rawson, AW Dempster, CM Humphreys… - Virulence, 2023 - Taylor & Francis
Clostridium botulinum, a polyphyletic Gram-positive taxon of bacteria, is classified purely by
their ability to produce botulinum neurotoxin (BoNT). BoNT is the primary virulence factor …

Pharmaceutical, biological, and clinical properties of botulinum neurotoxin type A products

J Frevert - Drugs in R&D, 2015 - Springer
Botulinum neurotoxin injections are a valuable treatment modality for many therapeutic
indications and have revolutionized the field of aesthetic medicine so that they are the …

Detection of toxins involved in foodborne diseases caused by Gram‐positive bacteria

A Rajkovic, J Jovanovic, S Monteiro… - … reviews in food …, 2020 - Wiley Online Library
Bacterial toxins are food safety hazards causing about 10% of all reported foodborne
outbreaks in Europe. Pertinent to Gram‐positive pathogens, the most relevant toxins are …

Botulinum toxin A, brain and pain

I Matak, Z Lacković - Progress in neurobiology, 2014 - Elsevier
Botulinum neurotoxin type A (BoNT/A) is one of the most potent toxins known and a potential
biological threat. At the same time, it is among the most widely used therapeutic proteins …

The long journey of botulinum neurotoxins into the synapse

A Rummel - Toxicon, 2015 - Elsevier
Botulinum neurotoxins (BoNT) cause the disease botulism, a flaccid paralysis of the muscle.
They are also very effective, widely used medicines applied locally in sub-nanogram …

Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity

K Lee, S Gu, L Jin, TTN Le, LW Cheng… - PLoS …, 2013 - journals.plos.org
Botulinum neurotoxins (BoNTs) are produced by Clostridium botulinum and cause the fatal
disease botulism, a flaccid paralysis of the muscle. BoNTs are released together with …

Botulinum toxin: pharmacology and injectable administration for the treatment of primary hyperhidrosis

S Nawrocki, J Cha - Journal of the American Academy of Dermatology, 2020 - Elsevier
Hyperhidrosis is a dermatological condition defined by excessive sweating beyond
thermoregulatory needs with significant effects on patients' quality of life. Hyperhidrosis is …

On botulinum neurotoxin variability

C Montecucco, MB Rasotto - MBio, 2015 - Am Soc Microbiol
The rapidly growing number of botulinum neurotoxin sequences poses the problem of the
possible evolutionary significance of the variability of these superpotent neurotoxins for toxin …

Why are botulinum neurotoxin-producing bacteria so diverse and botulinum neurotoxins so toxic?

B Poulain, MR Popoff - Toxins, 2019 - mdpi.com
Botulinum neurotoxins (BoNTs) are the most lethal toxins among all bacterial, animal, plant
and chemical poisonous compounds. Although a great effort has been made to understand …