Design of therapeutic biomaterials to control inflammation

Z Tu, Y Zhong, H Hu, D Shao, R Haag… - Nature Reviews …, 2022 - nature.com
Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

Toll-like receptors activation, signaling, and targeting: an overview

SR El-Zayat, H Sibaii, FA Mannaa - Bulletin of the National Research …, 2019 - Springer
Abstract Background Toll-like receptors (TLRs) are an important family of receptors that
constitute the first line of defense system against microbes. They can recognize both …

Magnetic nanoparticles in targeted drug delivery: a review

E Kianfar - Journal of Superconductivity and Novel Magnetism, 2021 - Springer
Magnetic nanoparticles are one of the most important and widely used types of
nanomaterials, whose unique properties make them special compared to other …

Gut microbiota and cardiovascular disease: opportunities and challenges

N Kazemian, M Mahmoudi, F Halperin, JC Wu… - Microbiome, 2020 - Springer
Coronary artery disease (CAD) is the most common health problem worldwide and remains
the leading cause of morbidity and mortality. Over the past decade, it has become clear that …

Inhibition of toll-like receptor signaling as a promising therapy for inflammatory diseases: a journey from molecular to nano therapeutics

W Gao, Y Xiong, Q Li, H Yang - Frontiers in physiology, 2017 - frontiersin.org
The recognition of invading pathogens and endogenous molecules from damaged tissues
by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However …

Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology

A Pant, I Mackraj, T Govender - Journal of Biomedical Science, 2021 - Springer
Sepsis, a dysregulated immune response due to life-threatening organ dysfunction, caused
by drug-resistant pathogens, is a major global health threat contributing to high disease …

Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases

JR Nakkala, Z Li, W Ahmad, K Wang, C Gao - Acta Biomaterialia, 2021 - Elsevier
The degree of tissue injuries such as the level of scarring or organ dysfunction, and the
immune response against them primarily determine the outcome and speed of healing …

Nanotools for sepsis diagnosis and treatment

L Papafilippou, A Claxton, P Dark… - Advanced …, 2021 - Wiley Online Library
Sepsis is one of the leading causes of death worldwide with high mortality rates and a
pathological complexity hindering early and accurate diagnosis. Today, laboratory culture …

Neutrophils and macrophages as targets for development of nanotherapeutics in inflammatory diseases

Y Su, J Gao, P Kaur, Z Wang - Pharmaceutics, 2020 - mdpi.com
Neutrophils and macrophages are major components of innate systems, playing central
roles in inflammation responses to infections and tissue injury. If they are out of control …

Designing inorganic nanomaterials for vaccines and immunotherapies

KL Hess, IL Medintz, CM Jewell - Nano Today, 2019 - Elsevier
Vaccines and immunotherapies have changed the face of health care. Biomaterials offer the
ability to improve upon these medical technologies through increased control of the types …