[HTML][HTML] Anticancer drug resistance: An update and perspective
R Nussinov, CJ Tsai, H Jang - Drug Resistance Updates, 2021 - Elsevier
Driver mutations promote initiation and progression of cancer. Pharmacological treatment
can inhibit the action of the mutant protein; however, drug resistance almost invariably …
can inhibit the action of the mutant protein; however, drug resistance almost invariably …
Mechanisms of enhancer action: the known and the unknown
A Panigrahi, BW O'Malley - Genome biology, 2021 - Springer
Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
The Sorghum bicolor reference genome: improved assembly, gene annotations, a transcriptome atlas, and signatures of genome organization
Sorghum bicolor is a drought tolerant C4 grass used for the production of grain, forage,
sugar, and lignocellulosic biomass and a genetic model for C4 grasses due to its relatively …
sugar, and lignocellulosic biomass and a genetic model for C4 grasses due to its relatively …
Identification of cancer driver genes based on nucleotide context
Cancer genomes contain large numbers of somatic mutations but few of these mutations
drive tumor development. Current approaches either identify driver genes on the basis of …
drive tumor development. Current approaches either identify driver genes on the basis of …
New insights into the generation and role of de novo mutations in health and disease
Aside from inheriting half of the genome of each of our parents, we are born with a small
number of novel mutations that occurred during gametogenesis and postzygotically. Recent …
number of novel mutations that occurred during gametogenesis and postzygotically. Recent …
H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure
Somatic mutations in driver genes may ultimately lead to the development of cancer.
Understanding how somatic mutations accumulate in cancer genomes and the underlying …
Understanding how somatic mutations accumulate in cancer genomes and the underlying …
Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion
Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood
(hUCB) holds great promise for treating a broad spectrum of hematological disorders …
(hUCB) holds great promise for treating a broad spectrum of hematological disorders …
Parent-of-origin-specific signatures of de novo mutations
De novo mutations (DNMs) originating in gametogenesis are an important source of genetic
variation. We use a data set of 7,216 autosomal DNMs with resolved parent of origin from …
variation. We use a data set of 7,216 autosomal DNMs with resolved parent of origin from …
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
Mutations are the source of genetic variation and the substrate for evolution. Genome-wide
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …