A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …

S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …

Synthesis of 3, 4-dihydropyrimidin (thio) one containing scaffold: Biginelli-like reactions

F Sánchez-Sancho, M Escolano, D Gaviña, AG Csáky… - Pharmaceuticals, 2022 - mdpi.com
The interest in 3, 4-dihydropyrimidine-2 (1 H)-(thio) ones is increasing every day, mainly due
to their paramount biological relevance. The Biginelli reaction is the classical approach to …

Simple dihydropyridine-based colorimetric chemosensors for heavy metal ion detection, biological evaluation, molecular docking, and ADMET profiling

WM Hamada, MN El-Nahass, AA Noser, TA Fayed… - Scientific Reports, 2023 - nature.com
In this study, two novel chemosensors containing dihydropyridine fragment namely;(2 E, 2 E
ʹ)-1, 1ʹ-(2, 6-dimethyl-1, 4-dihydropyridine-3, 5-diyl) bis (3-(4-(dimethylamino) phenyl) prop …

Novel diphenyl ether-heterocycles hybrids: Synthesis via Hantzsch and Biginelli reactions, molecular docking simulation, and antimicrobial activities

YA El-Gabry, ME Salem, NS Ibrahim… - Journal of Molecular …, 2024 - Elsevier
By reacting the potassium salt produced by treating 4-hydroxybenzaldehyde with ethanolic
KOH with 4-fluorobenzaldehyde in DMF at reflux, 4, 4′-oxydibenzaldehyde was produced …

A probe to surface reactivity, crystal structure, and DFT investigations for newly synthesized 4, 5-bis (4-Nitrophenyl)-8a-phenyl-decahydro-[1, 3] diazino [4, 5-d] …

Y El Bakri, M Kurbanova, A Ahsin, N Ramazanzade… - Crystals, 2023 - mdpi.com
The multicomponent reaction of 4-nitrobenzaldehyde with acetophenone and urea in the
presence of HCl was investigated, and, as a result, 4, 5-bis (4-nitrophenyl)-8a-phenyl …

Curcumin‐based bioactive heterocycles derived via multicomponent reactions

AA Nagargoje, MH Shaikh… - Archiv der Pharmazie, 2023 - Wiley Online Library
Curcumin is an important phytochemical, found in the Asian countries, especially in the
Indian subcontinent. The use of this “privileged natural product” in the diversity‐oriented …

Synthesis of phthalimide and naphthalimide derived Biginelli compounds and evaluation of their anti-inflammatory and anti-oxidant activities

P Totawar, R Varala, V Kotra… - Current Chemistry …, 2023 - growingscience.com
In the present work, synthesis of phthalimide and naphthalimide derived Biginelli
compounds was performed. Allylation of phthalic & naphthalic anhydride, followed by …

Hydroaminoalkyl Functionalization of Pyrimidin‐2(1H)‐ones by Visible Light Organophotocatalysis: A Radical Approach to Biginelli‐Type Dihydropyrimidines

O Lukianov, V Tkachuk, S Shishkina… - Advanced Synthesis …, 2023 - Wiley Online Library
Herein, we report a visible‐light‐mediated hydroaminoalkylation of pyrimidin‐2 (1H)‐ones
via the aza‐Giese‐type reaction in presence of acridinium dye as photocatalyst under mild …

Medicinal perspective of a promising scaffold–dihydropyrimidinones: A review

BH Sarvaiya, PI Vaja, NA Paghdar… - Journal of Heterocyclic …, 2024 - Wiley Online Library
Dihydropyrimidinones (DHMPs) are the most important pharmacophore in Medicinal
Chemistry. The synthetic approach for deriving DHMPs involves the Biginelli reaction or a …

Green synthesis of the ZnO/ZSM-5 composite by using Convolvulus persicus extract: As an efficient and reusable catalyst in the Biginelli reaction

E Roustaie, M Tajbakhsh, R Hosseinzadeh - Journal of Organometallic …, 2023 - Elsevier
The active catalytic materials in stable inorganic supports are increasingly developing for the
creation of ultra-stable catalysts with excellent performance. Here, the ZnO was supported …