Frontiers in electrochemical sensors for neurotransmitter detection: towards measuring neurotransmitters as chemical diagnostics for brain disorders

Y Ou, AM Buchanan, CE Witt, P Hashemi - Analytical Methods, 2019 - pubs.rsc.org
It is extremely challenging to chemically diagnose disorders of the brain. There is hence
great interest in designing and optimizing tools for direct detection of chemical biomarkers …

Electrochemistry at the Synapse

M Shin, Y Wang, JR Borgus… - Annual Review of …, 2019 - annualreviews.org
Electrochemical measurements of neurotransmitters provide insight into the dynamics of
neurotransmission. In this review, we describe the development of electrochemical …

In vivo ambient serotonin measurements at carbon-fiber microelectrodes

A Abdalla, CW Atcherley, P Pathirathna… - Analytical …, 2017 - ACS Publications
The mechanisms that control extracellular serotonin levels in vivo are not well-defined. This
shortcoming makes it very challenging to diagnose and treat the many psychiatric disorders …

Inflammation-induced histamine impairs the capacity of escitalopram to increase hippocampal extracellular serotonin

M Hersey, S Samaranayake, SN Berger… - Journal of …, 2021 - Soc Neuroscience
Commonly prescribed selective serotonin reuptake inhibitors (SSRIs) inhibit the serotonin
transporter to correct a presumed deficit in extracellular serotonin signaling during …

Mechanical stimulation of human hair follicle outer root sheath cultures activates adjacent sensory neurons

J Agramunt, B Parke, S Mena, V Ubels, F Jimenez… - Science …, 2023 - science.org
Mechanical stimuli, such as stroking or pressing on the skin, activate mechanoreceptors
transmitting information to the sensory nervous system and brain. It is well accepted that …

A tale of two transmitters: serotonin and histamine as in vivo biomarkers of chronic stress in mice

M Hersey, M Reneaux, SN Berger, S Mena… - Journal of …, 2022 - Springer
Background Stress-induced mental illnesses (mediated by neuroinflammation) pose one of
the world's most urgent public health challenges. A reliable in vivo chemical biomarker of …

Accurate and stable chronic in vivo voltammetry enabled by a replaceable subcutaneous reference electrode

EM Robbins, E Castagnola, XT Cui - Iscience, 2022 - cell.com
In vivo sensing of neurotransmitters has provided valuable insight into both healthy and
diseased brain. However, chronically implanted Ag/AgCl reference electrodes suffer from …

Serotonin is a common thread linking different classes of antidepressants

CE Witt, S Mena, J Holmes, M Hersey… - Cell chemical …, 2023 - cell.com
Depression pathology remains elusive. The monoamine hypothesis has placed much focus
on serotonin, but due to the variable clinical efficacy of monoamine reuptake inhibitors, the …

Electrochemical and biosensor techniques to monitor neurotransmitter changes with depression

KE Dunham, BJ Venton - Analytical and Bioanalytical Chemistry, 2024 - Springer
Depression is a common mental illness. However, its current treatments, like selective
serotonin reuptake inhibitors (SSRIs) and micro-dosing ketamine, are extremely variable …

Electrochemical Sensing of Serotonin by a Modified MnO2-Graphene Electrode

L Nehru, S Chinnathambi, E Fazio, F Neri, SG Leonardi… - Biosensors, 2020 - mdpi.com
The development of MnO2-graphene (MnO2-GR) composite by microwave irradiation
method and its application as an electrode material for the selective determination of …