Ribosomes are molecular machines that synthesize proteins in the cell. Recent biochemical
analyses and high-resolution crystal structures of the bacterial ribosome have shown that …

The catalytic mechanisms employed by RNA are chemically more diverse than initially
suspected. Divalent metal ions, nucleobases, ribosyl hydroxyl groups, and even functional …

We studied the pH-dependence of ribosome catalyzed peptidyl transfer from fMet-tRNAfMet
to the aa-tRNAs Phe-tRNAPhe, Ala-tRNAAla, Gly-tRNAGly, Pro-tRNAPro, Asn-tRNAAsn …

The peptidyl transferase center (PTC) in the large subunit of the ribosome plays a critical
role in protein synthesis by catalyzing the formation of peptide bonds with an astounding …

As a model for mechanistic comparison with peptidyl transfer within the ribosome, the
reaction of aqueous glycinamide with N-formylphenylalanine trifluoroethyl ester (fPhe-TFE) …

The free 2 '− 3 'cis-diol at the 3 '-terminus of tRNA provides a unique juxtaposition of
functional groups that play critical roles during protein synthesis. The translation process …

1. The ribosome 2042. Peptide bond formation is catalyzed by RNA 2053. Characteristics of
the uncatalyzed reaction 2074. Potential catalytic strategies of the ribosome 2075 …

The ribosome has an active site comprised of RNA that catalyzes peptide bond formation. To
understand how RNA promotes this reaction requires a detailed understanding of the …

Mechanistic studies of the action of catalytic ribonucleic acids, ribozymes, are highly
challenging, because even a slight structural change can dramatically affect the chain …

The principle of continuity posits that some central features of primordial biocatalytic
mechanisms should still be present in the genetically dependent pathway of protein …