Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders
R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …
complex genetic architectures but overlapping behavioral phenotypes, which suggests …
Shining a light on CNTNAP2: complex functions to complex disorders
The genetic basis of complex neurological disorders involving language are poorly
understood, partly due to the multiple additive genetic risk factors that are thought to be …
understood, partly due to the multiple additive genetic risk factors that are thought to be …
Genetic overlap between autism, schizophrenia and bipolar disorder
LS Carroll, MJ Owen - Genome medicine, 2009 - Springer
There is strong evidence that genetic factors make substantial contributions to the etiology of
autism, schizophrenia and bipolar disorders, with heritability estimates being at least 80 …
autism, schizophrenia and bipolar disorders, with heritability estimates being at least 80 …
Investigation of dyslexia and SLI risk variants in reading-and language-impaired subjects
Dyslexia (or reading disability) and specific language impairment (or SLI) are common
childhood disorders that show considerable co-morbidity and diagnostic overlaps and have …
childhood disorders that show considerable co-morbidity and diagnostic overlaps and have …
Behavioral phenotypes of genetic mouse models of autism
TM Kazdoba, PT Leach… - Genes, Brain and …, 2016 - Wiley Online Library
More than a hundred de novo single gene mutations and copy‐number variants have been
implicated in autism, each occurring in a small subset of cases. Mutant mouse models with …
implicated in autism, each occurring in a small subset of cases. Mutant mouse models with …
The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders
Recent advances in genetics and genomics have unveiled numerous cases of autism
spectrum disorders (ASDs) associated with rare, causal genetic variations. These findings …
spectrum disorders (ASDs) associated with rare, causal genetic variations. These findings …
Genetic advances in the study of speech and language disorders
DF Newbury, AP Monaco - Neuron, 2010 - cell.com
Developmental speech and language disorders cover a wide range of childhood conditions
with overlapping but heterogeneous phenotypes and underlying etiologies. This …
with overlapping but heterogeneous phenotypes and underlying etiologies. This …
Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons
O Varea, MD Martin-de-Saavedra… - Proceedings of the …, 2015 - National Acad Sciences
Central glutamatergic synapses and the molecular pathways that control them are emerging
as common substrates in the pathogenesis of mental disorders. Genetic variation in the …
as common substrates in the pathogenesis of mental disorders. Genetic variation in the …
Contact in the genetics of autism and schizophrenia
JPH Burbach, B van der Zwaag - Trends in neurosciences, 2009 - cell.com
Although autism and schizophrenia are considered to be distinct neuropsychiatric
developmental disorders, recent studies indicate that they share genetic factors. The same …
developmental disorders, recent studies indicate that they share genetic factors. The same …
[HTML][HTML] Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia
AT Pagnamenta, E Bacchelli, MV de Jonge, G Mirza… - Biological …, 2010 - Elsevier
BACKGROUND: Autism spectrum disorders (ASDs) are characterized by social,
communication, and behavioral deficits and complex genetic etiology. A recent study of 517 …
communication, and behavioral deficits and complex genetic etiology. A recent study of 517 …