Both acute proteotoxic stresses that unfold proteins and expression of disease-causing
mutant proteins that expose aggregation-prone regions can promote protein aggregation …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. A progressive deterioration in the ability of cells to preserve the …

Mitochondrial dysfunction has been widely accepted as a detrimental factor in subarachnoid
hemorrhage (SAH)-induced early brain injury (EBI), which is eminently related to poor …

Adaptive homeostasis is “the transient expansion or contraction of the homeostatic range for
any given physiological parameter in response to exposure to sub‐toxic, non‐damaging …

The reduction of oxidative stress could be achieved in three levels: by lowering exposure to
environmental pollutants with oxidizing properties, by increasing levels of endogenous and …

Calorie restriction (CR) robustly extends the lifespan of numerous species. In the yeast
Saccharomyces cerevisiae, CR has been proposed to extend lifespan by boosting the …

Oxidative stress arises when there is a marked imbalance between the production and
removal of reactive oxygen species (ROS) in favor of the prooxidant balance, leading to …

This review focuses on direct and indirect interactions between dissolved humic substances
(HS) and freshwater organisms and presents novel opinions and hypotheses on their …

Exposure to adverse environmental conditions causes oxidative stress in many organisms,
leading either to disease and debilitation or to response and tolerance. Mitochondria are a …

Since their discovery in Drosophila, the heat shock proteins (Hsps) have been shown to
regulate both stress resistance and life-span. Aging is characterized by increased oxidative …