Tackling COVID‐19 infection through complement‐targeted immunotherapy

S Jodele, J Köhl - British Journal of Pharmacology, 2021 - Wiley Online Library
The complement system is an ancient part of innate immunity sensing highly pathogenic
coronaviruses by mannan‐binding lectin (MBL) resulting in lectin pathway activation and …

BK virus: current understanding of pathogenicity and clinical disease in transplantation

S Chong, M Antoni, A Macdonald… - Reviews in Medical …, 2019 - Wiley Online Library
BK polyomavirus (BKV) is an important cause of graft loss in renal transplant recipients that
continues to pose a significant challenge to clinicians due to its frequently unpredictable …

Randomized trial to assess the clinical utility of renal allograft monitoring by urine CXCL10 chemokine

P Hirt-Minkowski, J Handschin, S Stampf… - Journal of the …, 2023 - journals.lww.com
Background Urine CXCL10 is a promising noninvasive biomarker for detection of renal
allograft rejection. The aim of this study was to investigate the clinical utility of renal allograft …

Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer

SC Baker, AS Mason, RG Slip, KT Skinner… - Oncogene, 2022 - nature.com
Limited understanding of bladder cancer aetiopathology hampers progress in reducing
incidence. Mutational signatures show the anti-viral apolipoprotein B mRNA editing enzyme …

Interferon-complement loop in transplant-associated thrombotic microangiopathy

S Jodele, M Medvedovic, N Luebbering… - Blood …, 2020 - ashpublications.org
Transplant-associated thrombotic microangiopathy (TA-TMA) is an important cause of
morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The …

Host and viral RNA dysregulation during BK polyomavirus infection in kidney transplant recipients

R Yaghobi, A Afshari, J Roozbeh - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Early detection of BK polyomavirus (BKPyV) infection in kidney transplant recipients (KTRs)
would enhance their quality of life and save the allograft. Still, many patients lose their …

Impaired CD4+ Cytotoxic T lymphocyte activity in polyomavirus BK infected kidney transplant recipients

N Noshadi, R Yaghoubi, A Afshari… - Iranian Journal of …, 2023 - ijaai.tums.ac.ir
The reactivation of polyomavirus BK (BKPyV) contributes to increased morbidity and
mortality rates of transplant patients, especially kidney transplant recipients (KTRs). CD4+ T …

The effect of the BK polyomavirus large T antigen on the function and maturity of the CD4+ T cell subsets in kidney transplant recipients

MR Foroudi, R Yaghobi, A Afshari, J Roozbeh… - Transplant …, 2023 - Elsevier
Background In kidney transplant recipients (KTRs) who are immunosuppressed, human BK
polyomavirus (BKPyV) infection can be reactivated, resulting in BKPyV-associated …

Pretransplant BKV-IgG serostatus and BKV-specific ELISPOT assays to predict BKV infection after kidney transplantation

H Bae, S Jung, BH Chung, CW Yang… - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Polyomavirus (BKV) infection can lead to major complications and damage to
the graft in kidney transplant recipients (KTRs). We investigated whether pretransplant BK …

[HTML][HTML] A systematic review and meta-analysis of enzyme-linked immunosorbent spot (ELISPOT) assay for BK polyomavirus immune response monitoring after …

S Udomkarnjananun, SJ Kerr, MI Francke… - Journal of Clinical …, 2021 - Elsevier
BK virus (BKV) infection after kidney transplantation can cause BKV nephropathy (BKVAN)
resulting in graft dysfunction and allograft loss. The treatment for BKVAN is reduction of the …