The tremendous public health problem created by substance use disorders (SUDs) presents
a major opportunity for mouse genetics. Inbred mouse strains exhibit substantial and …

Motivation Our ability to identify causative genetic factors for mouse genetic models of
human diseases and biomedical traits has been limited by the difficulties associated with …

Artificial intelligence (AI) has been used in many areas of medicine, and recently large
language models (LLMs) have shown potential utility for clinical applications. However …

The ability to use genome-wide association studies (GWAS) for genetic discovery depends
upon our ability to distinguish true causative from false positive association signals …

Short tandem repeats (STRs) play a crucial role in genetic diseases. However, classic
disease models such as inbred mice lack such genome wide data in public domain. The …

Genetic variation accounts for much of the risk for developing a substance use disorder
(SUD). Inbred mouse strains exhibit substantial and heritable differences in the extent of …

Mice are the most widely used animal model to study genotype to phenotype relationships.
Inbred mice are genetically identical, which eliminates genetic heterogeneity and makes …

Motivation The transport of proteins plays a crucial role in the cellular phenotype. Changes
in the protein targeting sequence can result in missing protein delivery to the right …