Fluorescence nanoscopy in cell biology
Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …
internal nanoscale structure and dynamics of cells and tissues with molecular detection …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
Super-resolving microscopy in neuroscience
Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …
system. The emergence of various super-resolution microscopy methods and specialized …
Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core
CL Hoop, HK Lin, K Kar… - Proceedings of the …, 2016 - National Acad Sciences
Polyglutamine expansion within the exon1 of huntingtin leads to protein misfolding,
aggregation, and cytotoxicity in Huntington's disease. This incurable neurodegenerative …
aggregation, and cytotoxicity in Huntington's disease. This incurable neurodegenerative …
Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington's disease
Huntington's disease (HD) is a neurodegenerative disorder caused by expansion of a CAG
trinucleotide repeat in the Huntingtin (HTT) gene, encoding a homopolymeric polyglutamine …
trinucleotide repeat in the Huntingtin (HTT) gene, encoding a homopolymeric polyglutamine …
Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core
HK Lin, JC Boatz, IE Krabbendam, R Kodali… - Nature …, 2017 - nature.com
Polyglutamine expansion in the huntingtin protein is the primary genetic cause of
Huntington's disease (HD). Fragments coinciding with mutant huntingtin exon1 aggregate in …
Huntington's disease (HD). Fragments coinciding with mutant huntingtin exon1 aggregate in …
The power of super-resolution microscopy in modern biomedical science
N Sun, Y Jia, S Bai, Q Li, L Dai, J Li - Advances in Colloid and Interface …, 2023 - Elsevier
Super-resolution microscopy (SRM) technology that breaks the diffraction limit has
revolutionized the field of cell biology since its appearance, which enables researchers to …
revolutionized the field of cell biology since its appearance, which enables researchers to …
Real-time imaging of Huntingtin aggregates diverting target search and gene transcription
The presumptive altered dynamics of transient molecular interactions in vivo contributing to
neurodegenerative diseases have remained elusive. Here, using single-molecule …
neurodegenerative diseases have remained elusive. Here, using single-molecule …
[HTML][HTML] Protofilament structure and supramolecular polymorphism of aggregated mutant huntingtin exon 1
Huntington's disease is a progressive neurodegenerative disease caused by expansion of
the polyglutamine domain in the first exon of huntingtin (HttEx1). The extent of expansion …
the polyglutamine domain in the first exon of huntingtin (HttEx1). The extent of expansion …
Quantitative NMR analysis of the kinetics of prenucleation oligomerization and aggregation of pathogenic huntingtin exon-1 protein
A Ceccon, V Tugarinov, F Torricella… - Proceedings of the …, 2022 - National Acad Sciences
The N-terminal region of the huntingtin protein, encoded by exon-1 (httex1) and containing
an expanded polyglutamine tract, forms fibrils that accumulate in neuronal inclusion bodies …
an expanded polyglutamine tract, forms fibrils that accumulate in neuronal inclusion bodies …