Hepatitis B virus persistence and reactivation

Y Shi, M Zheng - bmj, 2020 - bmj.com
Hepatitis B virus (HBV) infection causes chronic hepatitis and has long term complications.
Individuals ever infected with HBV are at risk of viral reactivation under certain …

Molecular mechanisms during hepatitis B infection and the effects of the virus variability

M Campos-Valdez, HC Monroy-Ramírez… - Viruses, 2021 - mdpi.com
The immunopathogenesis and molecular mechanisms involved during a hepatitis B virus
(HBV) infection have made the approaches for research complex, especially concerning the …

Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles

H Liu, X Hong, J Xi, S Menne, J Hu, JCY Wang - Science Advances, 2022 - science.org
The loss of detectable hepatitis B surface antigen (HBsAg) is considered a functional cure in
chronic hepatitis B. Naturally, HBsAg can be incorporated into the virion envelope or …

Characterization and application of precore/core‐related antigens in animal models of hepatitis B virus infection

X Hong, L Luckenbaugh, D Perlman, PA Revill… - …, 2021 - Wiley Online Library
Background and Aims The hepatitis B core‐related antigen (HBcrAg), a composite antigen
of precore/core gene including classical hepatitis B core protein (HBc) and HBeAg and …

Innate immunity and HBV persistence

C Chiale, AM Marchese, MD Robek - Current opinion in virology, 2021 - Elsevier
Hepatitis B virus (HBV) causes chronic infections that are associated with immune
dysfunction. Though T cell impairment is perhaps the most prominent immune change …

[HTML][HTML] Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer

M Suresh, S Menne - World Journal of Gastrointestinal Oncology, 2021 - ncbi.nlm.nih.gov
This review describes woodchucks chronically infected with the woodchuck hepatitis virus
(WHV) as an animal model for hepatocarcinogenesis and treatment of primary liver cancer …

Targeting host innate and adaptive immunity to achieve the functional cure of chronic hepatitis B

S Ezzikouri, ME Hoque Kayesh, S Benjelloun… - Vaccines, 2020 - mdpi.com
Despite the availability of an effective preventive vaccine for hepatitis B virus (HBV) for over
38 years, chronic HBV (CHB) infection remains a global health burden with around 257 …

Vitamin D role in hepatitis B: focus on immune system and genetics mechanism

A Asghari, F Jafari, M Jameshorani, H Chiti, M Naseri… - Heliyon, 2022 - cell.com
Abstract According to the World Health Organization (WHO) report, viral hepatitis has been a
problem in human society. Vitamins play a significant role in preventing the …

Recent drug development in the woodchuck model of chronic hepatitis B

M Suresh, S Menne - Viruses, 2022 - mdpi.com
Infection with hepatitis B virus (HBV) is responsible for the increasing global hepatitis
burden, with an estimated 296 million people being carriers and living with the risk of …

Agonistic activation of cytosolic DNA sensing receptors in woodchuck hepatocyte cultures and liver for inducing antiviral effects

M Suresh, B Li, X Huang, KE Korolowicz… - Frontiers in …, 2021 - frontiersin.org
Immune modulation for the treatment of chronic hepatitis B (CHB) has gained more traction
in recent years, with an increasing number of compounds designed for targeting different …