Metabolism is the sum of the enzyme‐dependent chemical reactions, which produces
energy in catabolic process and synthesizes biomass in anabolic process, exhibiting high …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

Increasing cellular immunogenicity and reshaping the immune tumor microenvironment
(TME) are crucial for antitumor immunotherapy. Herein, this work develops a novel single …

A malformed tumour vascular network provokes the nutrient‐deprived tumour
microenvironment (TME), which conversely activates endothelial cell (EC) functions and …

Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) is a
powerful analytical technique that provides spatially preserved detection and quantification …

Molecular carcinogenesis is a multistep process that involves acquired abnormalities in key
biological processes. The complexity of cancer pathogenesis is best illustrated in the six …

The intestine is a highly metabolic tissue, but the metabolic programs that influence
intestinal crypt proliferation, differentiation, and regeneration are still emerging. Here, we …

Despite tremendous progress in cancer treatment in recent years, treatment resistance is still
a major challenge for a great number of patients. One of the main causes is regulatory T …

As a population of homogeneous cells with both self-renewal and differentiation potential,
stem cell pools are highly compartmentalized and contain distinct subsets that exhibit stable …

Organoid technologies represent a major breakthrough in biomedical research since they
offer increasingly sophisticated models for studying biological mechanisms supporting …