Sexual dimorphism has been reported in various human diseases including autoimmune
diseases, neurological diseases, pulmonary arterial hypertension, and some types of …

Female eutherians transcriptionally silence one X chromosome to balance gene dosage
between the sexes. X-chromosome inactivation (XCI) is initiated by the lncRNA Xist, which …

Human in vitro oogenesis provides a framework for clarifying the mechanism of human
oogenesis. To create its benchmark, it is vital to promote in vitro oogenesis using a model …

X-chromosome inactivation is a paradigm of epigenetic transcriptional regulation. Female
human embryonic stem cells (hESCs) often undergo erosion of X-inactivation upon …

Human pluripotent stem cells (hPSCs) are a powerful tool for disease modeling of hard-to-
access tissues (such as the brain). Current protocols either direct neuronal differentiation …

Human pluripotent stem cells (hPSCs) regularly and irreversibly show the erosion of X
chromosome inactivation (XCI) by long non-coding RNA (lncRNA) XIST silencing, causing …

Metastasis is the primary cause of cancer-related death, with the dissemination and
colonization of primary tumor cells at the metastatic site facilitated by various molecules and …

Background Tatton-Brown-Rahman syndrome (TBRS; OMIM 615879), also known as DNA
methyltransferase 3 alpha (DNMT3A)-overgrowth syndrome (DOS), was first described by …

Background Variation in X chromosome inactivation (XCI) in human-induced pluripotent
stem cells (hiPSCs) can impact their ability to model biological sex biases. The gene-wise …

Abstract DNMT3A/B and TET1 play indispensable roles in regulating DNA methylation that
undergoes extensive reprogramming during mammalian embryogenesis. Yet the …