Tumor heterogeneity: preclinical models, emerging technologies, and future applications
Heterogeneity describes the differences among cancer cells within and between tumors. It
refers to cancer cells describing variations in morphology, transcriptional profiles …
refers to cancer cells describing variations in morphology, transcriptional profiles …
Implementing vertex dynamics models of cell populations in biology within a consistent computational framework
The dynamic behaviour of epithelial cell sheets plays a central role during development,
growth, disease and wound healing. These processes occur as a result of cell adhesion …
growth, disease and wound healing. These processes occur as a result of cell adhesion …
Comparing individual-based approaches to modelling the self-organization of multicellular tissues
The coordinated behaviour of populations of cells plays a central role in tissue growth and
renewal. Cells react to their microenvironment by modulating processes such as movement …
renewal. Cells react to their microenvironment by modulating processes such as movement …
[图书][B] Dynamics of cancer: mathematical foundations of oncology
D Wodarz, N Komarova - 2014 - books.google.com
The book aims to provide an introduction to mathematical models that describe the
dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for …
dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for …
Unraveling intestinal stem cell behavior with models of crypt dynamics
AJ Carulli, LC Samuelson, S Schnell - Integrative Biology, 2014 - academic.oup.com
The definition, regulation and function of intestinal stem cells (ISCs) has been hotly debated.
Recent discoveries have started to clarify the nature of ISCs, but many questions remain …
Recent discoveries have started to clarify the nature of ISCs, but many questions remain …
Computational models and simulations of cancer metastasis
S Anvari, S Nambiar, J Pang, N Maftoon - Archives of Computational …, 2021 - Springer
The dawn of the new era in precise diagnostic devices and personalized cancer treatment is
intertwined with computational models capable of integrating biochemical factors and …
intertwined with computational models capable of integrating biochemical factors and …
The intricate interplay between epigenetic events, alternative splicing and noncoding RNA deregulation in colorectal cancer
Colorectal cancer (CRC) results from a transformation of colonic epithelial cells into
adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of …
adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of …
J-SPACE: a Julia package for the simulation of spatial models of cancer evolution and of sequencing experiments
Background The combined effects of biological variability and measurement-related errors
on cancer sequencing data remain largely unexplored. However, the spatio-temporal …
on cancer sequencing data remain largely unexplored. However, the spatio-temporal …
Genomics and epigenomics of colorectal cancer
MR Schweiger, M Hussong, C Roehr… - … : Systems Biology and …, 2013 - Wiley Online Library
Colorectal cancer is one of the most common cancer types worldwide and accounts for
approximately 600,000 deaths annually. Work over the last decades has uncovered a …
approximately 600,000 deaths annually. Work over the last decades has uncovered a …
Determining the control networks regulating stem cell lineages in colonic crypts
J Yang, DE Axelrod, NL Komarova - Journal of theoretical biology, 2017 - Elsevier
The question of stem cell control is at the center of our understanding of tissue functioning,
both in healthy and cancerous conditions. It is well accepted that cellular fate decisions …
both in healthy and cancerous conditions. It is well accepted that cellular fate decisions …