The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell
death. The removal of damaged mitochondria through autophagy, a process called …

Background & Aims Defects in lysosome function and autophagy contribute to the
pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol …

Drug-induced liver injury (DILI) is an important clinical problem, which has received more
attention in recent decades. It can be induced by small chemical molecules, biological …

Autophagy has emerged as a critical lysosomal pathway that maintains cell function and
survival through the degradation of cellular components such as organelles and proteins …

Cellular homeostais, that is normally maintained through autophagy, is disrupted in
alcoholic liver disease (ALD). Because autophagy and exosome biogenesis share common …

Autophagy can selectively remove damaged organelles, including mitochondria, and, in
turn, protect against mitochondria‐damage–induced cell death. Acetaminophen (APAP) …

The term lipophagy is used to describe the autophagic degradation of lipid droplets, the
main lipid storage organelles of eukaryotic cells. Ever since its discovery in 2009, lipophagy …

Autophagy is an intracellular degradation system that breaks down damaged organelles or
damaged proteins using intracellular lysosomes. Recent studies have also revealed that …

Autophagy is a lysosomal degradation process that degrades long-lived cellular proteins
and damaged organelles as a critical cell survival mechanism in response to stress. We …