The selective degradation of many short-lived proteins in eukaryotic cells is carried out by
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …

Cell proliferation depends on the duplication of chromosomes followed by the segregation of
duplicates (sister chromatids) to opposite poles of the cell prior to cell division (cytokinesis) …

A vertebrate securin (vSecurin) was identified on the basis of its biochemical analogy to the
Pds1p protein of budding yeast and the Cut2p protein of fission yeast. The vSecurin protein …

We have demonstrated previously that the oncoprotein Mdm2 has a ubiquitin ligase activity
for the tumor suppressor p53 protein. In the present study, we characterize this ubiquitin …

The anaphase-promoting complex or cyclosome (APC/C) is a ubiquitin ligase that
polyubiquitinates specific substrates at precise times in the cell cycle, thereby triggering the …

Budding yeast initiates anaphase by activating the Cdc20-dependent anaphase-promoting
complex (APC). The mitotic activity of Cdc28 (Cdk1) is required to activate this form of the …

Selective degradation of cyclins, inhibitors of cyclin-dependent kinases and anaphase
inhibitors is responsible for several major cell cycle transitions. The degradation of these cell …

The SUMO-1 has been identified as a protein that is highly similar to ubiquitin and shown to
conjugate to RanGAP1, PML, Sp200 and I κ B α. The conjugation steps are thought to be …

▪ Abstract The faithful segregation of genetic information requires highly orchestrated
changes of chromosome structure during the mitotic cell cycle. The linkage between …

In the past 2 years, two ubiquitin‐dependent proteolytic pathways have been established as
important players in the regulation of the cell division cycle. In S. cerevisiae, the entry into S …