Transcriptional and epigenetic control of brown and beige adipose cell fate and function
White adipocytes store excess energy in the form of triglycerides, whereas brown and beige
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …
Transcriptional control of brown fat development
S Kajimura, P Seale, BM Spiegelman - Cell metabolism, 2010 - cell.com
Deconvoluting the natural pathway of BAT development has defined key molecular events,
which enables researchers to manipulate the amount or activity of brown fat. We review …
which enables researchers to manipulate the amount or activity of brown fat. We review …
Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity
S Ma, H Yu, Z Zhao, Z Luo, J Chen, Y Ni… - Journal of molecular …, 2012 - academic.oup.com
Brown adipose tissue (BAT) is an energy-expending organ that produces heat. Expansion or
activation of BAT prevents obesity and diabetes. Chronic cold exposure enhances …
activation of BAT prevents obesity and diabetes. Chronic cold exposure enhances …
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply
Background: Adrenergic activation of brown adipocytes mobilizes fatty acids for oxidation
and promotes transcription of oxidative genes. Results: Activation of adipocyte lipases …
and promotes transcription of oxidative genes. Results: Activation of adipocyte lipases …
L-arginine modulates glucose and lipid metabolism in obesity and diabetes
S Hu, M Han, A Rezaei, D Li, G Wu… - Current Protein and …, 2017 - ingentaconnect.com
Type 2 diabetes has become a global public health problem affecting approximately 380
million people throughout the world. It can cause many complications and lead to greater …
million people throughout the world. It can cause many complications and lead to greater …
NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection
N Volakakis, B Kadkhodaei… - Proceedings of the …, 2010 - National Acad Sciences
Induced expression of neuroprotective genes is essential for maintaining neuronal integrity
after stressful insults to the brain. Here we show that NR4A nuclear orphan receptors are …
after stressful insults to the brain. Here we show that NR4A nuclear orphan receptors are …
[HTML][HTML] Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity
M Derecka, A Gornicka, SB Koralov, K Szczepanek… - Cell metabolism, 2012 - cell.com
Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to
aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and …
aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and …
Resveratrol and lifespan in model organisms
Background: Resveratrol may possess life-prolonging and health-benefitting properties,
some of which may resemble the effect of caloric restriction (CR). CR appears to prolong the …
some of which may resemble the effect of caloric restriction (CR). CR appears to prolong the …
[HTML][HTML] SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex
H Shen, T He, S Wang, L Hou, Y Wei, Y Liu, C Mo… - Theranostics, 2022 - ncbi.nlm.nih.gov
Brown and beige fat protect against cold environments and obesity by catabolizing stored
energy to generate heat. This process is achieved by controlling thermogenesis-related …
energy to generate heat. This process is achieved by controlling thermogenesis-related …
l-Arginine promotes protein synthesis and cell growth in brown adipocyte precursor cells via the mTOR signal pathway
Abstract l-Arginine has been reported to enhance brown adipose tissue developments in
fetal lambs of obese ewes, but the underlying mechanism is unknown. The present study …
fetal lambs of obese ewes, but the underlying mechanism is unknown. The present study …