The signal transducer and activator of transcription (STAT) proteins have important roles in
biological processes. The abnormal activation of STAT signalling pathways is also …

Breast cancer is the most frequent cancer in women and represents the second leading
cause of cancer death among women (after lung cancer). The etiology of breast cancer is …

We report that breast cancer cells that infiltrate the lungs support their own metastasis-
initiating ability by expressing tenascin C (TNC). We find that the expression of TNC, an …

Signal transducers and activators of transcription 5 (STAT5a and STAT5b) are highly
homologous proteins that are encoded by 2 separate genes and are activated by Janus …

Signal transducer and activator of transcription (STAT) proteins are latent cytoplasmic
transcription factors that were discovered in the context of cytokine and growth factor …

Background The development and progression of estrogen receptor alpha positive (ERα+)
breast cancer has been linked epidemiologically to prolactin. However, activation of the …

Introduction Signal transducer and activator of transcription 3 (Stat3) is constitutively tyrosine-
phosphorylated in approximately 50% of primary breast carcinomas. A number of different …

Stats (for signal transducers and activators of transcription) are a family of transcription
factors that regulate cell growth and differentiation. Their activity is latent until …

Purpose Transcription factor signal transducer and activator of transcription-5 (Stat5)
promotes breast epithelial cell differentiation. We retrospectively analyzed whether levels of …

Clinically, circulating prolactin levels and density of the extracellular matrix (ECM) are
individual risk factors for breast cancer. As tumors develop, the surrounding stroma …